247100

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1374489..1375114 Replicon chromosome
Accession NZ_CP098211
Organism Escherichia coli strain Z0117EC0040

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag NBY16_RS06615 Protein ID WP_000911329.1
Coordinates 1374716..1375114 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NBY16_RS06610 Protein ID WP_000450524.1
Coordinates 1374489..1374716 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY16_RS06585 (1370291) 1370291..1370761 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
NBY16_RS06590 (1370761) 1370761..1371333 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NBY16_RS06595 (1371479) 1371479..1372357 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
NBY16_RS06600 (1372374) 1372374..1373408 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
NBY16_RS06605 (1373621) 1373621..1374334 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NBY16_RS06610 (1374489) 1374489..1374716 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NBY16_RS06615 (1374716) 1374716..1375114 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
NBY16_RS06620 (1375261) 1375261..1376124 + 864 WP_001267498.1 neutral zinc metallopeptidase -
NBY16_RS06625 (1376139) 1376139..1378154 + 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
NBY16_RS06630 (1378228) 1378228..1378926 + 699 WP_000679823.1 esterase -
NBY16_RS06635 (1379007) 1379007..1379207 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T247100 WP_000911329.1 NZ_CP098211:1374716-1375114 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT247100 WP_000450524.1 NZ_CP098211:1374489-1374716 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References