Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2444679..2445325 Replicon chromosome
Accession NC_014029
Organism Yersinia pestis Z176003

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag YPZ3_RS11370 Protein ID WP_002214976.1
Coordinates 2444679..2444861 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag YPZ3_RS11375 Protein ID WP_002211129.1
Coordinates 2444906..2445325 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPZ3_RS11335 2440064..2440534 + 471 WP_002227961.1 flagellar basal body-associated protein FliL -
YPZ3_RS11340 2440540..2441541 + 1002 WP_002211135.1 flagellar motor switch protein FliM -
YPZ3_RS11345 2441538..2441954 + 417 WP_002211134.1 flagellar motor switch protein FliN -
YPZ3_RS11350 2441954..2442490 + 537 WP_002211133.1 flagellar biosynthetic protein FliO -
YPZ3_RS11355 2442571..2443311 + 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
YPZ3_RS11360 2443457..2443687 + 231 WP_071821832.1 flagellar biosynthesis protein FliQ -
YPZ3_RS11365 2443690..2444472 + 783 WP_002211130.1 flagellar type III secretion system protein FliR -
YPZ3_RS11370 2444679..2444861 + 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
YPZ3_RS11375 2444906..2445325 + 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
YPZ3_RS11380 2445583..2446542 - 960 WP_002211128.1 sugar kinase -
YPZ3_RS11385 2446591..2447613 - 1023 WP_002214974.1 ABC transporter permease -
YPZ3_RS11390 2447616..2449193 - 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
YPZ3_RS11395 2449259..2450254 - 996 WP_002211125.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T24710 WP_002214976.1 NC_014029:2444679-2444861 [Yersinia pestis Z176003]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T24710 NC_014029:2444679-2444861 [Yersinia pestis Z176003]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT24710 WP_002211129.1 NC_014029:2444906-2445325 [Yersinia pestis Z176003]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT24710 NC_014029:2444906-2445325 [Yersinia pestis Z176003]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References