247098

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 943588..944242 Replicon chromosome
Accession NZ_CP098211
Organism Escherichia coli strain Z0117EC0040

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag NBY16_RS04570 Protein ID WP_000244772.1
Coordinates 943835..944242 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NBY16_RS04565 Protein ID WP_000354046.1
Coordinates 943588..943854 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY16_RS04540 (938757) 938757..939500 + 744 WP_000951964.1 SDR family oxidoreductase -
NBY16_RS04545 (939557) 939557..940990 - 1434 WP_001307385.1 6-phospho-beta-glucosidase BglA -
NBY16_RS04550 (941035) 941035..941346 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
NBY16_RS04555 (941510) 941510..942169 + 660 WP_000250274.1 hemolysin III family protein -
NBY16_RS04560 (942365) 942365..943345 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
NBY16_RS04565 (943588) 943588..943854 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NBY16_RS04570 (943835) 943835..944242 + 408 WP_000244772.1 protein YgfX Toxin
NBY16_RS04575 (944282) 944282..944803 - 522 WP_001055874.1 flavodoxin FldB -
NBY16_RS04580 (944915) 944915..945811 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NBY16_RS04585 (945836) 945836..946546 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NBY16_RS04590 (946552) 946552..948285 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T247098 WP_000244772.1 NZ_CP098211:943835-944242 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT247098 WP_000354046.1 NZ_CP098211:943588-943854 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References