247096

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 341955..342541 Replicon chromosome
Accession NZ_CP098211
Organism Escherichia coli strain Z0117EC0040

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag NBY16_RS01550 Protein ID WP_042014162.1
Coordinates 341955..342185 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag NBY16_RS01555 Protein ID WP_000593555.1
Coordinates 342182..342541 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY16_RS01540 (337992) 337992..340727 + 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -
NBY16_RS01545 (340727) 340727..341851 + 1125 WP_001314210.1 ABC transporter permease -
NBY16_RS01550 (341955) 341955..342185 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
NBY16_RS01555 (342182) 342182..342541 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NBY16_RS01560 (342661) 342661..343062 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
NBY16_RS01565 (343068) 343068..343874 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
NBY16_RS01570 (343871) 343871..344635 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
NBY16_RS01575 (344635) 344635..345468 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
NBY16_RS01580 (345465) 345465..346409 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T247096 WP_042014162.1 NZ_CP098211:341955-342185 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT247096 WP_000593555.1 NZ_CP098211:342182-342541 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References