Detailed information of TA system TA247092

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3929025..3930714
• Replicon: chromosome
• Accession: NZ_CP098210
• Organism: Escherichia coli strain Z0117EC0051

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: V0Z9M0
• Locus tag: NBY17_RS18595
• Protein ID: WP_000365809.1
• Coordinates: 3929025..3929945 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: NBY17_RS18600
• Protein ID: WP_001550661.1
• Coordinates: 3929932..3930714 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NBY17_RS18580 (3925115)	3925115..3926242	-	1128	WP_001550663.1	MFS transporter	-
NBY17_RS18585 (3926384)	3926384..3927442	-	1059	WP_122987197.1	alpha/beta hydrolase	-
NBY17_RS18590 (3927707)	3927707..3928591	+	885	WP_001119037.1	LysR family transcriptional regulator	-
NBY17_RS18595 (3929025)	3929025..3929945	-	921	WP_000365809.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
NBY17_RS18600 (3929932)	3929932..3930714	-	783	WP_001550661.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
NBY17_RS18605 (3931030)	3931030..3934239	+	3210	WP_001521910.1	RNA-directed DNA polymerase	-
NBY17_RS18610 (3934586)	3934586..3935056	+	471	WP_000201185.1	hypothetical protein	-
NBY17_RS18615 (3935053)	3935053..3935155	+	103	Protein_3647	helix-turn-helix domain-containing protein	-
NBY17_RS18620 (3935247)	3935247..3935405	+	159	Protein_3648	integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-261)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-247)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34571.01 Da
• Isoelectric Point: 7.2649

>T247092 WP_000365809.1 NZ_CP098210:c3929945-3929025 [Escherichia coli]
MDLRDSYARQVKLLMAALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29191.43 Da
• Isoelectric Point: 8.9059

>AT247092 WP_001550661.1 NZ_CP098210:c3930714-3929932 [Escherichia coli]
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQSQWEKPVRVAGLT
SLALQGHAHYTEQGKPQVWLALPAYVKLPGWFSAFEQSATFVTLYTSGLTADVTPFTTELKIGDRQLAGSVPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSVKTNRVMLYLARRNGHPYFQYIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: V0Z9M0