Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3723797..3724415 Replicon chromosome
Accession NZ_CP098210
Organism Escherichia coli strain Z0117EC0051

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NBY17_RS17635 Protein ID WP_001291435.1
Coordinates 3724197..3724415 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NBY17_RS17630 Protein ID WP_000344800.1
Coordinates 3723797..3724171 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY17_RS17620 (3718886) 3718886..3720079 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NBY17_RS17625 (3720102) 3720102..3723251 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
NBY17_RS17630 (3723797) 3723797..3724171 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NBY17_RS17635 (3724197) 3724197..3724415 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NBY17_RS17640 (3724587) 3724587..3725138 + 552 WP_000102564.1 maltose O-acetyltransferase -
NBY17_RS17645 (3725254) 3725254..3725724 + 471 WP_000136192.1 YlaC family protein -
NBY17_RS17650 (3725888) 3725888..3727438 + 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NBY17_RS17655 (3727480) 3727480..3727833 - 354 WP_001550741.1 DUF1428 family protein -
NBY17_RS17665 (3728212) 3728212..3728523 + 312 WP_000409911.1 MGMT family protein -
NBY17_RS17670 (3728554) 3728554..3729126 - 573 WP_086773737.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T247091 WP_001291435.1 NZ_CP098210:3724197-3724415 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT247091 WP_000344800.1 NZ_CP098210:3723797-3724171 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References