Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3321260..3321965 Replicon chromosome
Accession NZ_CP098210
Organism Escherichia coli strain Z0117EC0051

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag NBY17_RS15860 Protein ID WP_000539521.1
Coordinates 3321260..3321646 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NBY17_RS15865 Protein ID WP_001280945.1
Coordinates 3321636..3321965 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY17_RS15840 (3317264) 3317264..3317890 + 627 WP_001295292.1 glutathione S-transferase GstB -
NBY17_RS15845 (3317887) 3317887..3319002 - 1116 WP_000555051.1 aldose sugar dehydrogenase YliI -
NBY17_RS15850 (3319113) 3319113..3319496 - 384 WP_000497137.1 biofilm formation regulator BssR -
NBY17_RS15855 (3319709) 3319709..3321034 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
NBY17_RS15860 (3321260) 3321260..3321646 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY17_RS15865 (3321636) 3321636..3321965 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
NBY17_RS15870 (3322035) 3322035..3323363 - 1329 WP_001550887.1 GGDEF domain-containing protein -
NBY17_RS15875 (3323371) 3323371..3325719 - 2349 WP_001550886.1 EAL domain-containing protein -
NBY17_RS15880 (3325897) 3325897..3326808 - 912 Protein_3116 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T247090 WP_000539521.1 NZ_CP098210:3321260-3321646 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT247090 WP_001280945.1 NZ_CP098210:3321636-3321965 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References