Detailed information of TA system TA024709

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 1983702..1984668
• Replicon: chromosome
• Accession: NC_014029
• Organism: Yersinia pestis Z176003

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E8XJV6
• Locus tag: YPZ3_RS09090
• Protein ID: WP_002210981.1
• Coordinates: 1983702..1984160 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: YPZ3_RS09095
• Protein ID: WP_002210982.1
• Coordinates: 1984222..1984668 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YPZ3_RS09060	1979516..1980181	+	666	WP_002210975.1	phage shock protein PspA	-
YPZ3_RS09065	1980343..1980570	+	228	WP_002210976.1	envelope stress response membrane protein PspB	-
YPZ3_RS09070	1980570..1980929	+	360	WP_002210977.1	envelope stress response membrane protein PspC	-
YPZ3_RS09075	1981014..1981256	+	243	WP_002216375.1	phage shock protein PspD	-
YPZ3_RS09080	1981237..1982634	+	1398	WP_002210979.1	YcjX family protein	-
YPZ3_RS09085	1982631..1983692	+	1062	WP_002210980.1	YcjF family protein	-
YPZ3_RS09090	1983702..1984160	-	459	WP_002210981.1	RES family NAD+ phosphorylase	Toxin
YPZ3_RS09095	1984222..1984668	-	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
YPZ3_RS09100	1985003..1986580	+	1578	WP_002210983.1	transcriptional regulator TyrR	-
YPZ3_RS09105	1986727..1987185	-	459	WP_002213775.1	IS200/IS605-like element IS1541B family transposase	-
YPZ3_RS09110	1987438..1987941	-	504	WP_002210984.1	thiol peroxidase	-
YPZ3_RS09115	1988104..1989078	+	975	WP_002210985.1	L-Ala-D/L-Glu epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1986727..1987185	458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16994.38 Da
• Isoelectric Point: 4.8732

>T24709 WP_002210981.1 NC_014029:c1984160-1983702 [Yersinia pestis Z176003]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T24709 NC_014029:c1984160-1983702 [Yersinia pestis Z176003]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT24709 WP_002210982.1 NC_014029:c1984668-1984222 [Yersinia pestis Z176003]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT24709 NC_014029:c1984668-1984222 [Yersinia pestis Z176003]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: A0A0E8XJV6

Antitoxin

• AlphaFold DB: A0A0E8XFL1