Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3065868..3066652 Replicon chromosome
Accession NZ_CP098210
Organism Escherichia coli strain Z0117EC0051

Toxin (Protein)


Gene name TacT2 Uniprot ID V0T0H9
Locus tag NBY17_RS14650 Protein ID WP_000613626.1
Coordinates 3066158..3066652 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID L4JCW6
Locus tag NBY17_RS14645 Protein ID WP_001110447.1
Coordinates 3065868..3066161 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY17_RS14635 (3061018) 3061018..3061977 - 960 WP_000846342.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -
NBY17_RS14640 (3062550) 3062550..3065735 + 3186 WP_001550951.1 ribonuclease E -
NBY17_RS14645 (3065868) 3065868..3066161 + 294 WP_001110447.1 DUF1778 domain-containing protein Antitoxin
NBY17_RS14650 (3066158) 3066158..3066652 + 495 WP_000613626.1 GNAT family N-acetyltransferase Toxin
NBY17_RS14655 (3066747) 3066747..3067700 - 954 WP_001212768.1 flagellar hook-associated protein FlgL -
NBY17_RS14660 (3067712) 3067712..3069355 - 1644 WP_000096478.1 flagellar hook-associated protein FlgK -
NBY17_RS14665 (3069421) 3069421..3070362 - 942 WP_001366226.1 flagellar assembly peptidoglycan hydrolase FlgJ -
NBY17_RS14670 (3070362) 3070362..3071459 - 1098 WP_001441925.1 flagellar basal body P-ring protein FlgI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(81-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18084.00 Da        Isoelectric Point: 8.2617

>T247089 WP_000613626.1 NZ_CP098210:3066158-3066652 [Escherichia coli]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIGRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11109.69 Da        Isoelectric Point: 10.5423

>AT247089 WP_001110447.1 NZ_CP098210:3065868-3066161 [Escherichia coli]
MPAANNIPTRRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0T0H9

Antitoxin

Source ID Structure
AlphaFold DB L4JCW6

References