Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/UPF0150(antitoxin) |
| Location | 2683683..2684321 | Replicon | chromosome |
| Accession | NZ_CP098210 | ||
| Organism | Escherichia coli strain Z0117EC0051 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A7U9DHD1 |
| Locus tag | NBY17_RS12710 | Protein ID | WP_000813795.1 |
| Coordinates | 2684145..2684321 (-) | Length | 59 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | NBY17_RS12705 | Protein ID | WP_076797675.1 |
| Coordinates | 2683683..2684099 (-) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NBY17_RS12685 (2678835) | 2678835..2679776 | - | 942 | WP_001251315.1 | ABC transporter permease | - |
| NBY17_RS12690 (2679777) | 2679777..2680790 | - | 1014 | WP_001551095.1 | ABC transporter ATP-binding protein | - |
| NBY17_RS12695 (2680808) | 2680808..2681953 | - | 1146 | WP_001551094.1 | ABC transporter substrate-binding protein | - |
| NBY17_RS12700 (2682198) | 2682198..2683604 | - | 1407 | WP_001551093.1 | PLP-dependent aminotransferase family protein | - |
| NBY17_RS12705 (2683683) | 2683683..2684099 | - | 417 | WP_076797675.1 | type II toxin-antitoxin system antitoxin HicB | Antitoxin |
| NBY17_RS12710 (2684145) | 2684145..2684321 | - | 177 | WP_000813795.1 | type II toxin-antitoxin system mRNA interferase toxin HicA | Toxin |
| NBY17_RS12715 (2684543) | 2684543..2684773 | + | 231 | WP_023910283.1 | YncJ family protein | - |
| NBY17_RS12720 (2684865) | 2684865..2686826 | - | 1962 | WP_001551090.1 | 23S rRNA 5-hydroxycytidine C2501 synthase | - |
| NBY17_RS12725 (2686899) | 2686899..2687435 | - | 537 | WP_001551089.1 | DNA-binding transcriptional regulator SutR | - |
| NBY17_RS12730 (2687527) | 2687527..2688699 | + | 1173 | WP_001551088.1 | BenE family transporter YdcO | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6747.80 Da Isoelectric Point: 11.5666
>T247088 WP_000813795.1 NZ_CP098210:c2684321-2684145 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS
Download Length: 177 bp
Antitoxin
Download Length: 139 a.a. Molecular weight: 15220.55 Da Isoelectric Point: 4.7386
>AT247088 WP_076797675.1 NZ_CP098210:c2684099-2683683 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV
Download Length: 417 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|