Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 469628..470125 Replicon chromosome
Accession NZ_CP098210
Organism Escherichia coli strain Z0117EC0051

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NBY17_RS02075 Protein ID WP_001173343.1
Coordinates 469952..470125 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag NBY17_RS02070 Protein ID WP_000398619.1
Coordinates 469628..469924 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY17_RS02050 (466358) 466358..467077 - 720 WP_000611288.1 two-component system response regulator DcuR -
NBY17_RS02055 (467074) 467074..468705 - 1632 WP_001216477.1 sensor histidine kinase -
NBY17_RS02060 (468885) 468885..469115 + 231 WP_001550470.1 4Fe-4S mono-cluster protein YjdI -
NBY17_RS02065 (469127) 469127..469399 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
NBY17_RS02070 (469628) 469628..469924 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NBY17_RS02075 (469952) 469952..470125 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NBY17_RS02080 (470244) 470244..471761 - 1518 WP_001550472.1 lysine--tRNA ligase -
NBY17_RS02085 (471998) 471998..473455 - 1458 WP_001550473.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T247076 WP_001173343.1 NZ_CP098210:469952-470125 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT247076 WP_000398619.1 NZ_CP098210:469628-469924 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References