Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4563530..4564027 Replicon chromosome
Accession NZ_CP098206
Organism Escherichia coli strain Z0117EC0054

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NBY18_RS22385 Protein ID WP_001173343.1
Coordinates 4563530..4563703 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag NBY18_RS22390 Protein ID WP_001312331.1
Coordinates 4563731..4564027 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY18_RS22375 (4560200) 4560200..4561657 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
NBY18_RS22380 (4561894) 4561894..4563411 + 1518 WP_000003806.1 lysine--tRNA ligase -
NBY18_RS22385 (4563530) 4563530..4563703 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NBY18_RS22390 (4563731) 4563731..4564027 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NBY18_RS22395 (4564255) 4564255..4564527 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
NBY18_RS22400 (4564539) 4564539..4564769 - 231 WP_000373293.1 4Fe-4S mono-cluster protein YjdI -
NBY18_RS22405 (4564950) 4564950..4566581 + 1632 WP_001216482.1 sensor histidine kinase -
NBY18_RS22410 (4566578) 4566578..4567297 + 720 WP_000611291.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - papX 4492355..4564027 71672


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T247071 WP_001173343.1 NZ_CP098206:c4563703-4563530 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT247071 WP_001312331.1 NZ_CP098206:c4564027-4563731 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References