Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1070858..1071530 Replicon chromosome
Accession NC_014029
Organism Yersinia pestis Z176003

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag YPZ3_RS04835 Protein ID WP_002215144.1
Coordinates 1071105..1071530 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag YPZ3_RS04830 Protein ID WP_002209939.1
Coordinates 1070858..1071124 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPZ3_RS04810 1066715..1067818 + 1104 WP_002209943.1 hypothetical protein -
YPZ3_RS04815 1068020..1068721 + 702 WP_002209942.1 hemolysin III family protein -
YPZ3_RS04820 1068979..1069476 + 498 WP_002209941.1 DUF2165 family protein -
YPZ3_RS04825 1069549..1070541 - 993 WP_002209940.1 tRNA-modifying protein YgfZ -
YPZ3_RS04830 1070858..1071124 + 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
YPZ3_RS04835 1071105..1071530 + 426 WP_002215144.1 protein YgfX Toxin
YPZ3_RS04840 1071530..1072228 + 699 WP_002209937.1 two-component system response regulator CreB -
YPZ3_RS04845 1072253..1073671 + 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
YPZ3_RS04850 1073792..1075249 + 1458 WP_002220113.1 cell envelope integrity protein CreD -
YPZ3_RS04855 1075339..1075857 - 519 WP_002209934.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T24707 WP_002215144.1 NC_014029:1071105-1071530 [Yersinia pestis Z176003]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T24707 NC_014029:1071105-1071530 [Yersinia pestis Z176003]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT24707 WP_002209939.1 NC_014029:1070858-1071124 [Yersinia pestis Z176003]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT24707 NC_014029:1070858-1071124 [Yersinia pestis Z176003]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References