Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX(toxin)
Location 4285860..4286674 Replicon chromosome
Accession NZ_CP098206
Organism Escherichia coli strain Z0117EC0054

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag NBY18_RS20975 Protein ID WP_001054376.1
Coordinates 4285860..4286117 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID A0A8E0IVE5
Locus tag NBY18_RS20980 Protein ID WP_001350781.1
Coordinates 4286129..4286674 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY18_RS20950 (4281148) 4281148..4282254 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
NBY18_RS20955 (4282319) 4282319..4283299 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
NBY18_RS20960 (4283409) 4283409..4283614 + 206 Protein_4109 HNH endonuclease -
NBY18_RS20965 (4283882) 4283882..4285122 - 1241 Protein_4110 helicase YjhR -
NBY18_RS20970 (4285238) 4285238..4285369 + 132 WP_001309182.1 hypothetical protein -
NBY18_RS20975 (4285860) 4285860..4286117 + 258 WP_001054376.1 YjhX family toxin Toxin
NBY18_RS20980 (4286129) 4286129..4286674 + 546 WP_001350781.1 N-acetyltransferase Antitoxin
NBY18_RS20985 (4286730) 4286730..4287476 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
NBY18_RS20990 (4287645) 4287645..4287863 + 219 Protein_4115 hypothetical protein -
NBY18_RS20995 (4287901) 4287901..4288017 + 117 Protein_4116 VOC family protein -
NBY18_RS21000 (4288262) 4288262..4289383 + 1122 WP_000010832.1 M42 family metallopeptidase -
NBY18_RS21005 (4289380) 4289380..4289658 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
NBY18_RS21010 (4289670) 4289670..4290983 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 4275645..4294898 19253


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T247069 WP_001054376.1 NZ_CP098206:4285860-4286117 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19974.91 Da        Isoelectric Point: 6.3277

>AT247069 WP_001350781.1 NZ_CP098206:4286129-4286674 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAFIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure

References