Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3685327..3685945 Replicon chromosome
Accession NZ_CP098206
Organism Escherichia coli strain Z0117EC0054

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NBY18_RS18130 Protein ID WP_001291435.1
Coordinates 3685727..3685945 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NBY18_RS18125 Protein ID WP_000344800.1
Coordinates 3685327..3685701 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY18_RS18115 (3680417) 3680417..3681610 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NBY18_RS18120 (3681633) 3681633..3684782 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NBY18_RS18125 (3685327) 3685327..3685701 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NBY18_RS18130 (3685727) 3685727..3685945 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NBY18_RS18135 (3686119) 3686119..3686670 + 552 WP_000102543.1 maltose O-acetyltransferase -
NBY18_RS18140 (3686786) 3686786..3687256 + 471 WP_000136192.1 YlaC family protein -
NBY18_RS18145 (3687420) 3687420..3688970 + 1551 WP_001350616.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NBY18_RS18150 (3689012) 3689012..3689365 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NBY18_RS18160 (3689744) 3689744..3690055 + 312 WP_000409908.1 MGMT family protein -
NBY18_RS18165 (3690086) 3690086..3690658 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T247066 WP_001291435.1 NZ_CP098206:3685727-3685945 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT247066 WP_000344800.1 NZ_CP098206:3685327-3685701 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References