Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2577852..2579440 Replicon chromosome
Accession NZ_CP098206
Organism Escherichia coli strain Z0117EC0054

Toxin (Protein)


Gene name hipA Uniprot ID B7MMY1
Locus tag NBY18_RS12520 Protein ID WP_001125475.1
Coordinates 2578118..2579440 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NBY18_RS12515 Protein ID WP_001332145.1
Coordinates 2577852..2578118 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY18_RS12500 (2574220) 2574220..2575671 + 1452 WP_000854637.1 tagaturonate reductase -
NBY18_RS12505 (2575868) 2575868..2576782 + 915 WP_001306069.1 bestrophin family protein -
NBY18_RS12510 (2576786) 2576786..2577544 - 759 WP_001286588.1 trans-aconitate 2-methyltransferase -
NBY18_RS12515 (2577852) 2577852..2578118 + 267 WP_001332145.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NBY18_RS12520 (2578118) 2578118..2579440 + 1323 WP_001125475.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
NBY18_RS12525 (2579750) 2579750..2579932 - 183 Protein_2459 hypothetical protein -
NBY18_RS12530 (2580066) 2580066..2580848 + 783 WP_001221834.1 SDR family oxidoreductase -
NBY18_RS12535 (2581092) 2581092..2581199 - 108 Protein_2461 hypothetical protein -
NBY18_RS12540 (2581624) 2581624..2582187 + 564 WP_001296074.1 type 1 fimbrial major subunit FimA -
NBY18_RS12545 (2582549) 2582549..2583259 + 711 WP_001195181.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49426.24 Da        Isoelectric Point: 8.9380

>T247063 WP_001125475.1 NZ_CP098206:2578118-2579440 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRRNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVMCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.44 Da        Isoelectric Point: 6.2267

>AT247063 WP_001332145.1 NZ_CP098206:2577852-2578118 [Escherichia coli]
MMSFQKIYSPMQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPNNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2L5M8

Antitoxin

Source ID Structure

References