Detailed information of TA system TA247043

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3836531..3838220
• Replicon: chromosome
• Accession: NZ_CP098203
• Organism: Escherichia coli strain Z0117EC0055

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: NBY19_RS18900
• Protein ID: WP_000365807.1
• Coordinates: 3836531..3837451 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: NBY19_RS18905
• Protein ID: WP_001295795.1
• Coordinates: 3837438..3838220 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NBY19_RS18860 (3832004)	3832004..3832714	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
NBY19_RS18865 (3833021)	3833021..3833350	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
NBY19_RS18870 (3833362)	3833362..3833528	-	167	Protein_3705	tail fiber assembly protein	-
NBY19_RS18875 (3833599)	3833599..3834213	-	615	WP_001019923.1	YagU family protein	-
NBY19_RS18880 (3834428)	3834428..3834613	-	186	WP_000146240.1	hypothetical protein	-
NBY19_RS18885 (3834662)	3834662..3834820	+	159	Protein_3708	integrase	-
NBY19_RS18890 (3835047)	3835047..3835382	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
NBY19_RS18895 (3835590)	3835590..3836366	+	777	WP_000171155.1	site-specific integrase	-
NBY19_RS18900 (3836531)	3836531..3837451	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
NBY19_RS18905 (3837438)	3837438..3838220	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
NBY19_RS18910 (3838504)	3838504..3841602	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3796318..3845287	48969

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T247043 WP_000365807.1 NZ_CP098203:c3837451-3836531 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT247043 WP_001295795.1 NZ_CP098203:c3838220-3837438 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0