Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3653242..3653860 Replicon chromosome
Accession NZ_CP098203
Organism Escherichia coli strain Z0117EC0055

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NBY19_RS18035 Protein ID WP_001291435.1
Coordinates 3653642..3653860 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NBY19_RS18030 Protein ID WP_000344800.1
Coordinates 3653242..3653616 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY19_RS18020 (3648331) 3648331..3649524 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NBY19_RS18025 (3649547) 3649547..3652696 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
NBY19_RS18030 (3653242) 3653242..3653616 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NBY19_RS18035 (3653642) 3653642..3653860 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NBY19_RS18040 (3654033) 3654033..3654584 + 552 WP_000102539.1 maltose O-acetyltransferase -
NBY19_RS18045 (3654700) 3654700..3655170 + 471 WP_000136192.1 YlaC family protein -
NBY19_RS18050 (3655334) 3655334..3656884 + 1551 WP_001545832.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NBY19_RS18055 (3656926) 3656926..3657279 - 354 WP_000878147.1 DUF1428 family protein -
NBY19_RS18065 (3657658) 3657658..3657969 + 312 WP_000409908.1 MGMT family protein -
NBY19_RS18070 (3658000) 3658000..3658572 - 573 WP_000779841.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T247042 WP_001291435.1 NZ_CP098203:3653642-3653860 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT247042 WP_000344800.1 NZ_CP098203:3653242-3653616 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References