Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 988179..988833 Replicon chromosome
Accession NZ_CP098203
Organism Escherichia coli strain Z0117EC0055

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag NBY19_RS04860 Protein ID WP_000244765.1
Coordinates 988426..988833 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag NBY19_RS04855 Protein ID WP_000354050.1
Coordinates 988179..988445 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY19_RS04835 (984267) 984267..985700 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
NBY19_RS04840 (985745) 985745..986056 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
NBY19_RS04845 (986220) 986220..986879 + 660 WP_000250275.1 hemolysin III family protein -
NBY19_RS04850 (986956) 986956..987936 - 981 WP_000886080.1 tRNA-modifying protein YgfZ -
NBY19_RS04855 (988179) 988179..988445 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
NBY19_RS04860 (988426) 988426..988833 + 408 WP_000244765.1 protein YgfX Toxin
NBY19_RS04865 (988873) 988873..989394 - 522 WP_001055874.1 flavodoxin FldB -
NBY19_RS04870 (989506) 989506..990402 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NBY19_RS04875 (990427) 990427..991137 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NBY19_RS04880 (991143) 991143..992876 + 1734 WP_250844065.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T247032 WP_000244765.1 NZ_CP098203:988426-988833 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT247032 WP_000354050.1 NZ_CP098203:988179-988445 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References