Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 332912..333712 Replicon chromosome
Accession NZ_CP098203
Organism Escherichia coli strain Z0117EC0055

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag NBY19_RS01560 Protein ID WP_000342452.1
Coordinates 333185..333712 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag NBY19_RS01555 Protein ID WP_001277107.1
Coordinates 332912..333178 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY19_RS01535 (328571) 328571..329239 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
NBY19_RS01540 (329232) 329232..330290 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
NBY19_RS01545 (330535) 330535..331389 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
NBY19_RS01550 (331660) 331660..332763 + 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
NBY19_RS01555 (332912) 332912..333178 + 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
NBY19_RS01560 (333185) 333185..333712 + 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
NBY19_RS01565 (333709) 333709..334092 - 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
NBY19_RS01570 (334515) 334515..335624 + 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
NBY19_RS01575 (335672) 335672..336598 + 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
NBY19_RS01580 (336595) 336595..337872 + 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
NBY19_RS01585 (337869) 337869..338636 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T247028 WP_000342452.1 NZ_CP098203:333185-333712 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT247028 WP_001277107.1 NZ_CP098203:332912-333178 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References