Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 15028..15653 Replicon plasmid pZ0117EC0056-1
Accession NZ_CP098202
Organism Escherichia coli strain Z0117EC0056

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NBY20_RS24865 Protein ID WP_000911324.1
Coordinates 15255..15653 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag NBY20_RS24860 Protein ID WP_000450532.1
Coordinates 15028..15255 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY20_RS24860 (15028) 15028..15255 + 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin
NBY20_RS24865 (15255) 15255..15653 + 399 WP_000911324.1 type II toxin-antitoxin system VapC family toxin Toxin
NBY20_RS24870 (15662) 15662..16825 - 1164 Protein_20 type IV secretion system DNA-binding domain-containing protein -
NBY20_RS24875 (16878) 16878..17582 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
NBY20_RS24880 (17626) 17626..17724 + 99 Protein_22 complement resistance protein TraT -
NBY20_RS24885 (17977) 17977..18975 + 999 Protein_23 type IV secretion system DNA-binding domain-containing protein -
NBY20_RS24890 (19038) 19038..19742 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
NBY20_RS24895 (19748) 19748..20172 + 425 Protein_25 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sitABCD / mph(A) / sul1 / qacE / dfrA5 - 1..78537 78537


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14800.09 Da        Isoelectric Point: 7.8604

>T247024 WP_000911324.1 NZ_CP098202:15255-15653 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMEVIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELALQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT247024 WP_000450532.1 NZ_CP098202:15028-15255 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References