Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4136166..4136820 Replicon chromosome
Accession NZ_CP098201
Organism Escherichia coli strain Z0117EC0056

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag NBY20_RS19835 Protein ID WP_000244781.1
Coordinates 4136166..4136573 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0V9GG32
Locus tag NBY20_RS19840 Protein ID WP_001564007.1
Coordinates 4136554..4136820 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY20_RS19815 (4132123) 4132123..4133856 - 1734 WP_001564004.1 single-stranded-DNA-specific exonuclease RecJ -
NBY20_RS19820 (4133862) 4133862..4134572 - 711 WP_001564005.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NBY20_RS19825 (4134597) 4134597..4135493 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NBY20_RS19830 (4135605) 4135605..4136126 + 522 WP_001055874.1 flavodoxin FldB -
NBY20_RS19835 (4136166) 4136166..4136573 - 408 WP_000244781.1 protein YgfX Toxin
NBY20_RS19840 (4136554) 4136554..4136820 - 267 WP_001564007.1 FAD assembly factor SdhE Antitoxin
NBY20_RS19845 (4137063) 4137063..4138043 + 981 WP_001564008.1 tRNA-modifying protein YgfZ -
NBY20_RS19850 (4138120) 4138120..4138779 - 660 WP_000250274.1 hemolysin III family protein -
NBY20_RS19855 (4138943) 4138943..4139254 - 312 WP_001182966.1 N(4)-acetylcytidine aminohydrolase -
NBY20_RS19860 (4139299) 4139299..4140732 + 1434 WP_001564009.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T247019 WP_000244781.1 NZ_CP098201:c4136573-4136166 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10565.15 Da        Isoelectric Point: 5.1599

>AT247019 WP_001564007.1 NZ_CP098201:c4136820-4136554 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWMMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9GG32

References