Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2471235..2471873 Replicon chromosome
Accession NZ_CP098201
Organism Escherichia coli strain Z0117EC0056

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag NBY20_RS11960 Protein ID WP_000813795.1
Coordinates 2471235..2471411 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NBY20_RS11965 Protein ID WP_076797675.1
Coordinates 2471457..2471873 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY20_RS11940 (2466857) 2466857..2468029 - 1173 WP_001551088.1 BenE family transporter YdcO -
NBY20_RS11945 (2468121) 2468121..2468657 + 537 WP_001551089.1 DNA-binding transcriptional regulator SutR -
NBY20_RS11950 (2468730) 2468730..2470691 + 1962 WP_001551090.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NBY20_RS11955 (2470783) 2470783..2471013 - 231 WP_023910283.1 YncJ family protein -
NBY20_RS11960 (2471235) 2471235..2471411 + 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NBY20_RS11965 (2471457) 2471457..2471873 + 417 WP_076797675.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NBY20_RS11970 (2471952) 2471952..2473358 + 1407 WP_001551093.1 PLP-dependent aminotransferase family protein -
NBY20_RS11975 (2473603) 2473603..2474748 + 1146 WP_001551094.1 ABC transporter substrate-binding protein -
NBY20_RS11980 (2474766) 2474766..2475779 + 1014 WP_001551095.1 ABC transporter ATP-binding protein -
NBY20_RS11985 (2475780) 2475780..2476721 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T247011 WP_000813795.1 NZ_CP098201:2471235-2471411 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15220.55 Da        Isoelectric Point: 4.7386

>AT247011 WP_076797675.1 NZ_CP098201:2471457-2471873 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1

Antitoxin

Source ID Structure

References