Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1786597..1787302 Replicon chromosome
Accession NZ_CP098201
Organism Escherichia coli strain Z0117EC0056

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag NBY20_RS08490 Protein ID WP_000539521.1
Coordinates 1786916..1787302 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NBY20_RS08485 Protein ID WP_001280945.1
Coordinates 1786597..1786926 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY20_RS08470 (1781754) 1781754..1782665 + 912 WP_001236042.1 glutathione ABC transporter permease GsiD -
NBY20_RS08475 (1782843) 1782843..1785191 + 2349 WP_001550886.1 EAL domain-containing protein -
NBY20_RS08480 (1785199) 1785199..1786527 + 1329 WP_001550887.1 GGDEF domain-containing protein -
NBY20_RS08485 (1786597) 1786597..1786926 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
NBY20_RS08490 (1786916) 1786916..1787302 - 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY20_RS08495 (1787528) 1787528..1788853 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
NBY20_RS08500 (1789066) 1789066..1789449 + 384 WP_000497137.1 biofilm formation regulator BssR -
NBY20_RS08505 (1789560) 1789560..1790675 + 1116 WP_000555051.1 aldose sugar dehydrogenase YliI -
NBY20_RS08510 (1790672) 1790672..1791298 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T247006 WP_000539521.1 NZ_CP098201:c1787302-1786916 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT247006 WP_001280945.1 NZ_CP098201:c1786926-1786597 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References