Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1383343..1383961 Replicon chromosome
Accession NZ_CP098201
Organism Escherichia coli strain Z0117EC0056

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NBY20_RS06705 Protein ID WP_001291435.1
Coordinates 1383343..1383561 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NBY20_RS06710 Protein ID WP_000344800.1
Coordinates 1383587..1383961 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY20_RS06670 (1378632) 1378632..1379204 + 573 WP_000779831.1 YbaY family lipoprotein -
NBY20_RS06675 (1379235) 1379235..1379546 - 312 WP_000409911.1 MGMT family protein -
NBY20_RS06685 (1379925) 1379925..1380278 + 354 WP_001550741.1 DUF1428 family protein -
NBY20_RS06690 (1380320) 1380320..1381870 - 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NBY20_RS06695 (1382034) 1382034..1382504 - 471 WP_000136192.1 YlaC family protein -
NBY20_RS06700 (1382620) 1382620..1383171 - 552 WP_000102564.1 maltose O-acetyltransferase -
NBY20_RS06705 (1383343) 1383343..1383561 - 219 WP_001291435.1 HHA domain-containing protein Toxin
NBY20_RS06710 (1383587) 1383587..1383961 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NBY20_RS06715 (1384507) 1384507..1387656 - 3150 WP_001132480.1 efflux RND transporter permease AcrB -
NBY20_RS06720 (1387679) 1387679..1388872 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T247005 WP_001291435.1 NZ_CP098201:c1383561-1383343 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT247005 WP_000344800.1 NZ_CP098201:c1383961-1383587 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References