Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 585762..586284 Replicon chromosome
Accession NZ_CP098201
Organism Escherichia coli strain Z0117EC0056

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag NBY20_RS02765 Protein ID WP_001105433.1
Coordinates 585994..586284 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag NBY20_RS02760 Protein ID WP_000212715.1
Coordinates 585762..586004 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY20_RS02740 (581481) 581481..582854 + 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
NBY20_RS02745 (583004) 583004..583555 - 552 WP_000166270.1 ribosome biogenesis factor YjgA -
NBY20_RS02750 (583649) 583649..585001 + 1353 WP_001162173.1 metalloprotease PmbA -
NBY20_RS02755 (585184) 585184..585570 + 387 WP_001232246.1 cytochrome b562 -
NBY20_RS02760 (585762) 585762..586004 + 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NBY20_RS02765 (585994) 585994..586284 + 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY20_RS02770 (586285) 586285..586749 - 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NBY20_RS02775 (586929) 586929..589067 - 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
NBY20_RS02780 (589461) 589461..591116 - 1656 WP_001550509.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T247002 WP_001105433.1 NZ_CP098201:585994-586284 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT247002 WP_000212715.1 NZ_CP098201:585762-586004 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References