Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 19414..19949 Replicon plasmid pZ0117EC0062-3
Accession NZ_CP098200
Organism Escherichia coli strain Z0117EC0062

Toxin (Protein)


Gene name relE Uniprot ID T1PX77
Locus tag NBY21_RS25055 Protein ID WP_001523468.1
Coordinates 19662..19949 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8H9BAF4
Locus tag NBY21_RS25050 Protein ID WP_021560314.1
Coordinates 19414..19665 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY21_RS25030 (15007) 15007..15540 - 534 WP_021560316.1 transcription termination/antitermination NusG family protein -
NBY21_RS25035 (15986) 15986..16273 - 288 WP_019842580.1 conjugal transfer protein TraA -
NBY21_RS25040 (16311) 16311..16454 - 144 Protein_19 ash family protein -
NBY21_RS25045 (17430) 17430..18461 + 1032 WP_024227073.1 plasmid replication initiator RepA -
NBY21_RS25050 (19414) 19414..19665 + 252 WP_021560314.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NBY21_RS25055 (19662) 19662..19949 + 288 WP_001523468.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY21_RS25060 (19959) 19959..20504 + 546 WP_001523466.1 hypothetical protein -
NBY21_RS25065 (20800) 20800..21387 + 588 WP_064550130.1 colanic acid biosynthesis acetyltransferase -
NBY21_RS25070 (21667) 21667..22260 - 594 WP_001523457.1 ProQ/FINO family protein -
NBY21_RS25075 (23263) 23263..24030 + 768 WP_064550128.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..91127 91127


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11142.18 Da        Isoelectric Point: 10.6741

>T246995 WP_001523468.1 NZ_CP098200:19662-19949 [Escherichia coli]
MTYTVKFRDDALREWLRLDKAIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSHVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9198.42 Da        Isoelectric Point: 4.0927

>AT246995 WP_021560314.1 NZ_CP098200:19414-19665 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T1PX77

Antitoxin

Source ID Structure

References