Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4548448..4548945 Replicon chromosome
Accession NZ_CP098197
Organism Escherichia coli strain Z0117EC0062

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NBY21_RS21755 Protein ID WP_001173343.1
Coordinates 4548448..4548621 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag NBY21_RS21760 Protein ID WP_000398619.1
Coordinates 4548649..4548945 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY21_RS21745 (4545118) 4545118..4546575 + 1458 WP_001550473.1 dipeptide/tripeptide permease DtpC -
NBY21_RS21750 (4546812) 4546812..4548329 + 1518 WP_001550472.1 lysine--tRNA ligase -
NBY21_RS21755 (4548448) 4548448..4548621 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NBY21_RS21760 (4548649) 4548649..4548945 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NBY21_RS21765 (4549174) 4549174..4549446 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
NBY21_RS21770 (4549458) 4549458..4549688 - 231 WP_001550470.1 4Fe-4S mono-cluster protein YjdI -
NBY21_RS21775 (4549868) 4549868..4551499 + 1632 WP_001216477.1 sensor histidine kinase -
NBY21_RS21780 (4551496) 4551496..4552215 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T246988 WP_001173343.1 NZ_CP098197:c4548621-4548448 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT246988 WP_000398619.1 NZ_CP098197:c4548945-4548649 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References