Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4439649..4440171 Replicon chromosome
Accession NZ_CP098197
Organism Escherichia coli strain Z0117EC0062

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag NBY21_RS21190 Protein ID WP_001105433.1
Coordinates 4439649..4439939 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag NBY21_RS21195 Protein ID WP_000212715.1
Coordinates 4439929..4440171 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY21_RS21175 (4434817) 4434817..4436472 + 1656 WP_001550509.1 alpha,alpha-phosphotrehalase -
NBY21_RS21180 (4436866) 4436866..4439004 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
NBY21_RS21185 (4439184) 4439184..4439648 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NBY21_RS21190 (4439649) 4439649..4439939 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY21_RS21195 (4439929) 4439929..4440171 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NBY21_RS21200 (4440363) 4440363..4440749 - 387 WP_001232246.1 cytochrome b562 -
NBY21_RS21205 (4440932) 4440932..4442284 - 1353 WP_001162173.1 metalloprotease PmbA -
NBY21_RS21210 (4442378) 4442378..4442929 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
NBY21_RS21215 (4443079) 4443079..4444452 - 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T246986 WP_001105433.1 NZ_CP098197:c4439939-4439649 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT246986 WP_000212715.1 NZ_CP098197:c4440171-4439929 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References