246977

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3297725..3298430 Replicon chromosome
Accession NZ_CP098197
Organism Escherichia coli strain Z0117EC0062

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag NBY21_RS15920 Protein ID WP_000539521.1
Coordinates 3297725..3298111 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NBY21_RS15925 Protein ID WP_001280945.1
Coordinates 3298101..3298430 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY21_RS15900 (3293729) 3293729..3294355 + 627 WP_001295292.1 glutathione S-transferase GstB -
NBY21_RS15905 (3294352) 3294352..3295467 - 1116 WP_000555051.1 aldose sugar dehydrogenase YliI -
NBY21_RS15910 (3295578) 3295578..3295961 - 384 WP_000497137.1 biofilm formation regulator BssR -
NBY21_RS15915 (3296174) 3296174..3297499 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
NBY21_RS15920 (3297725) 3297725..3298111 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY21_RS15925 (3298101) 3298101..3298430 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
NBY21_RS15930 (3298500) 3298500..3299828 - 1329 WP_001550887.1 GGDEF domain-containing protein -
NBY21_RS15935 (3299836) 3299836..3302184 - 2349 WP_001550886.1 EAL domain-containing protein -
NBY21_RS15940 (3302362) 3302362..3303273 - 912 Protein_3125 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T246977 WP_000539521.1 NZ_CP098197:3297725-3298111 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT246977 WP_001280945.1 NZ_CP098197:3298101-3298430 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References