Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2659437..2660075 Replicon chromosome
Accession NZ_CP098197
Organism Escherichia coli strain Z0117EC0062

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag NBY21_RS12760 Protein ID WP_000813795.1
Coordinates 2659899..2660075 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NBY21_RS12755 Protein ID WP_076797675.1
Coordinates 2659437..2659853 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY21_RS12735 (2654589) 2654589..2655530 - 942 WP_001251315.1 ABC transporter permease -
NBY21_RS12740 (2655531) 2655531..2656544 - 1014 WP_001551095.1 ABC transporter ATP-binding protein -
NBY21_RS12745 (2656562) 2656562..2657707 - 1146 WP_001551094.1 ABC transporter substrate-binding protein -
NBY21_RS12750 (2657952) 2657952..2659358 - 1407 WP_001551093.1 PLP-dependent aminotransferase family protein -
NBY21_RS12755 (2659437) 2659437..2659853 - 417 WP_076797675.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NBY21_RS12760 (2659899) 2659899..2660075 - 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NBY21_RS12765 (2660297) 2660297..2660527 + 231 WP_023910283.1 YncJ family protein -
NBY21_RS12770 (2660619) 2660619..2662580 - 1962 WP_001551090.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NBY21_RS12775 (2662653) 2662653..2663189 - 537 WP_001551089.1 DNA-binding transcriptional regulator SutR -
NBY21_RS12780 (2663281) 2663281..2664453 + 1173 WP_001551088.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T246975 WP_000813795.1 NZ_CP098197:c2660075-2659899 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15220.55 Da        Isoelectric Point: 4.7386

>AT246975 WP_076797675.1 NZ_CP098197:c2659853-2659437 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1

Antitoxin

Source ID Structure

References