Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4597165..4597662 Replicon chromosome
Accession NZ_CP098195
Organism Escherichia coli strain Z0117EC0098

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NBY23_RS22500 Protein ID WP_001173343.1
Coordinates 4597165..4597338 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag NBY23_RS22505 Protein ID WP_000398619.1
Coordinates 4597366..4597662 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY23_RS22490 (4593835) 4593835..4595292 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
NBY23_RS22495 (4595529) 4595529..4597046 + 1518 WP_001295074.1 lysine--tRNA ligase -
NBY23_RS22500 (4597165) 4597165..4597338 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NBY23_RS22505 (4597366) 4597366..4597662 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NBY23_RS22510 (4597889) 4597889..4598161 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
NBY23_RS22515 (4598173) 4598173..4598403 - 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
NBY23_RS22520 (4598584) 4598584..4600215 + 1632 WP_001216461.1 sensor histidine kinase -
NBY23_RS22525 (4600212) 4600212..4600931 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T246958 WP_001173343.1 NZ_CP098195:c4597338-4597165 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT246958 WP_000398619.1 NZ_CP098195:c4597662-4597366 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References