Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4494658..4495253 Replicon chromosome
Accession NZ_CP098195
Organism Escherichia coli strain Z0117EC0098

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag NBY23_RS21985 Protein ID WP_000239579.1
Coordinates 4494658..4495008 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag NBY23_RS21990 Protein ID WP_001223208.1
Coordinates 4495002..4495253 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY23_RS21965 (4489934) 4489934..4490956 - 1023 WP_001339490.1 ABC transporter permease -
NBY23_RS21970 (4490970) 4490970..4492472 - 1503 WP_000205793.1 sugar ABC transporter ATP-binding protein -
NBY23_RS21975 (4492782) 4492782..4493738 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NBY23_RS21980 (4494048) 4494048..4494578 + 531 WP_000055072.1 inorganic diphosphatase -
NBY23_RS21985 (4494658) 4494658..4495008 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
NBY23_RS21990 (4495002) 4495002..4495253 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NBY23_RS21995 (4495466) 4495466..4495807 - 342 WP_063100134.1 gamma-glutamylcyclotransferase -
NBY23_RS22000 (4495810) 4495810..4499589 - 3780 WP_000060901.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T246957 WP_000239579.1 NZ_CP098195:c4495008-4494658 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT246957 WP_001223208.1 NZ_CP098195:c4495253-4495002 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References