Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3825119..3825956 Replicon chromosome
Accession NZ_CP098195
Organism Escherichia coli strain Z0117EC0098

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag NBY23_RS18890 Protein ID WP_000227784.1
Coordinates 3825414..3825956 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag NBY23_RS18885 Protein ID WP_001297137.1
Coordinates 3825119..3825430 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY23_RS18860 (3820139) 3820139..3821086 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
NBY23_RS18865 (3821108) 3821108..3823099 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
NBY23_RS18870 (3823089) 3823089..3823703 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
NBY23_RS18875 (3823703) 3823703..3824032 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
NBY23_RS18880 (3824044) 3824044..3824934 + 891 WP_000971336.1 heme o synthase -
NBY23_RS18885 (3825119) 3825119..3825430 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
NBY23_RS18890 (3825414) 3825414..3825956 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
NBY23_RS18895 (3826012) 3826012..3826946 - 935 Protein_3711 tetratricopeptide repeat protein -
NBY23_RS18900 (3827354) 3827354..3828718 + 1365 WP_001000978.1 MFS transporter -
NBY23_RS18905 (3828846) 3828846..3829337 - 492 WP_001138904.1 nucleotide binding protein YajQ -
NBY23_RS18910 (3829505) 3829505..3830416 + 912 WP_000705847.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T246955 WP_000227784.1 NZ_CP098195:3825414-3825956 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT246955 WP_001297137.1 NZ_CP098195:3825119-3825430 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References