Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3791042..3791660 Replicon chromosome
Accession NZ_CP098195
Organism Escherichia coli strain Z0117EC0098

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NBY23_RS18720 Protein ID WP_001291435.1
Coordinates 3791442..3791660 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NBY23_RS18715 Protein ID WP_000344800.1
Coordinates 3791042..3791416 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY23_RS18705 (3786131) 3786131..3787324 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NBY23_RS18710 (3787347) 3787347..3790496 + 3150 WP_191650283.1 efflux RND transporter permease AcrB -
NBY23_RS18715 (3791042) 3791042..3791416 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NBY23_RS18720 (3791442) 3791442..3791660 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NBY23_RS18725 (3791832) 3791832..3792383 + 552 WP_000102568.1 maltose O-acetyltransferase -
NBY23_RS18730 (3792499) 3792499..3792969 + 471 WP_000136192.1 YlaC family protein -
NBY23_RS18735 (3793133) 3793133..3794683 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NBY23_RS18740 (3794725) 3794725..3795078 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NBY23_RS18750 (3795457) 3795457..3795768 + 312 WP_000409911.1 MGMT family protein -
NBY23_RS18755 (3795799) 3795799..3796371 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T246954 WP_001291435.1 NZ_CP098195:3791442-3791660 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT246954 WP_000344800.1 NZ_CP098195:3791042-3791416 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References