Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2454157..2454795 Replicon chromosome
Accession NZ_CP098195
Organism Escherichia coli strain Z0117EC0098

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NBY23_RS12280 Protein ID WP_000813794.1
Coordinates 2454157..2454333 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NBY23_RS12285 Protein ID WP_001270286.1
Coordinates 2454379..2454795 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY23_RS12260 (2449776) 2449776..2450951 - 1176 WP_001236319.1 BenE family transporter YdcO -
NBY23_RS12265 (2451043) 2451043..2451579 + 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
NBY23_RS12270 (2451652) 2451652..2453613 + 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NBY23_RS12275 (2453705) 2453705..2453935 - 231 WP_000494244.1 YncJ family protein -
NBY23_RS12280 (2454157) 2454157..2454333 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NBY23_RS12285 (2454379) 2454379..2454795 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NBY23_RS12290 (2454874) 2454874..2456280 + 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
NBY23_RS12295 (2456525) 2456525..2457670 + 1146 WP_000047456.1 ABC transporter substrate-binding protein -
NBY23_RS12300 (2457688) 2457688..2458701 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
NBY23_RS12305 (2458702) 2458702..2459643 + 942 WP_001251319.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T246947 WP_000813794.1 NZ_CP098195:2454157-2454333 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT246947 WP_001270286.1 NZ_CP098195:2454379-2454795 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References