Detailed information of TA system TA024694

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 508098..508629
• Replicon: chromosome
• Accession: NC_014006
• Organism: Sphingobium japonicum UT26S

Toxin (Protein)

• Gene name: relE
• Uniprot ID: T0GNF5
• Locus tag: SJA_RS02370
• Protein ID: WP_004212690.1
• Coordinates: 508098..508379 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: T0G968
• Locus tag: SJA_RS02375
• Protein ID: WP_004212689.1
• Coordinates: 508366..508629 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SJA_RS02355	505296..505847	+	552	WP_041386225.1	recombinase family protein	-
SJA_RS02360	505844..506632	+	789	WP_013039098.1	SDR family NAD(P)-dependent oxidoreductase	-
SJA_RS02365	507031..507696	-	666	Protein_467	SDR family NAD(P)-dependent oxidoreductase	-
SJA_RS02370	508098..508379	-	282	WP_004212690.1	type II toxin-antitoxin system YafQ family toxin	Toxin
SJA_RS02375	508366..508629	-	264	WP_004212689.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
SJA_RS02380	509014..509451	-	438	WP_007683347.1	metal-binding protein	-
SJA_RS02385	509531..510772	-	1242	WP_007683345.1	MFS transporter	-
SJA_RS02390	510766..511752	-	987	WP_013039100.1	copper resistance protein B	-
SJA_RS02395	511749..513455	-	1707	WP_013039101.1	copper resistance system multicopper oxidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-76)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10993.49 Da
• Isoelectric Point: 7.4752

>T24694 WP_004212690.1 NC_014006:c508379-508098 [Sphingobium japonicum UT26S]
MRTIERFGRFKRDYKREKKGQHAKTLDADLIPIIEALASDEPLEPRHRDHALTGDWRDHRDCHIKPDLVLIYRKPDDDTL
QLVRLGSHAELGW

Nucleotide

• Length: 282 bp

>T24694 NC_014006:c508379-508098 [Sphingobium japonicum UT26S]
ATGCGGACGATTGAACGCTTCGGGCGGTTCAAGCGCGACTACAAGCGGGAGAAGAAGGGGCAGCACGCCAAGACGCTGGA
CGCTGACCTGATCCCGATCATCGAGGCGCTGGCATCCGACGAGCCGCTTGAACCGCGCCACCGCGACCATGCGCTGACCG
GCGACTGGCGCGACCATCGCGATTGCCACATAAAGCCCGACCTCGTGCTGATTTACCGCAAGCCCGATGACGACACCTTG
CAGCTTGTGCGCTTGGGATCGCACGCGGAATTGGGTTGGTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9284.75 Da
• Isoelectric Point: 4.5881

>AT24694 WP_004212689.1 NC_014006:c508629-508366 [Sphingobium japonicum UT26S]
MAANALVQTRIDGAVKEEAATVLAAMGLTVSDAVRLMLTRVARDKALPFEPLVPNAETIEAMKEAREGKGKRFATVVDLM
ADLNADD

Nucleotide

• Length: 264 bp

>AT24694 NC_014006:c508629-508366 [Sphingobium japonicum UT26S]
ATGGCCGCAAACGCTCTTGTGCAGACCCGGATCGACGGAGCGGTGAAGGAGGAAGCCGCGACCGTGCTGGCTGCTATGGG
GCTGACCGTCTCCGATGCCGTGCGCCTGATGCTGACCCGCGTTGCCCGCGACAAGGCCTTGCCGTTTGAACCGCTGGTGC
CCAATGCCGAGACGATCGAGGCCATGAAGGAAGCGCGCGAGGGAAAGGGCAAGCGGTTCGCCACGGTGGTCGACCTGATG
GCCGACCTCAATGCGGACGATTGA

Structures

Toxin

• AlphaFold DB: T0GNF5

Antitoxin

• AlphaFold DB: T0G968