Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 123104..123747 Replicon plasmid pZ0117ECO0116-1
Accession NZ_CP098193
Organism Escherichia coli strain Z0117EC0116

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag NBY24_RS24510 Protein ID WP_001034044.1
Coordinates 123331..123747 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1P7N7
Locus tag NBY24_RS24505 Protein ID WP_001261286.1
Coordinates 123104..123334 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY24_RS24490 (118241) 118241..118471 + 231 WP_001261278.1 type II toxin-antitoxin system VapB family antitoxin -
NBY24_RS24495 (118468) 118468..118884 + 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin -
NBY24_RS24500 (118929) 118929..122723 - 3795 WP_001144732.1 hypothetical protein -
NBY24_RS24505 (123104) 123104..123334 + 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NBY24_RS24510 (123331) 123331..123747 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
NBY24_RS24515 (123822) 123822..125387 + 1566 WP_001128474.1 AAA family ATPase -
NBY24_RS24520 (125372) 125372..126394 + 1023 WP_032174242.1 helicase UvrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD vat / iutA / iucD / iucC / iucB / iucA / iroB / iroC / iroD / iroE / iroN 1..192025 192025
- flank IS/Tn - - 126648..127151 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15232.66 Da        Isoelectric Point: 6.8536

>T246932 WP_001034044.1 NZ_CP098193:123331-123747 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEALLKHLEQSVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAACAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8747.86 Da        Isoelectric Point: 4.3775

>AT246932 WP_001261286.1 NZ_CP098193:123104-123334 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMTEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure
AlphaFold DB A0A829CKZ6

References