Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 69413..70038 Replicon plasmid pZ0117ECO0116-1
Accession NZ_CP098193
Organism Escherichia coli strain Z0117EC0116

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NBY24_RS24195 Protein ID WP_000911333.1
Coordinates 69640..70038 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag NBY24_RS24190 Protein ID WP_000450520.1
Coordinates 69413..69640 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY24_RS24190 (69413) 69413..69640 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
NBY24_RS24195 (69640) 69640..70038 + 399 WP_000911333.1 tRNA(fMet)-specific endonuclease VapC Toxin
NBY24_RS24200 (70047) 70047..72200 - 2154 WP_000009379.1 type IV conjugative transfer system coupling protein TraD -
NBY24_RS24205 (72453) 72453..73184 - 732 WP_000850416.1 conjugal transfer complement resistance protein TraT -
NBY24_RS24210 (73198) 73198..73707 - 510 WP_000628105.1 conjugal transfer entry exclusion protein TraS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD vat / iutA / iucD / iucC / iucB / iucA / iroB / iroC / iroD / iroE / iroN 1..192025 192025


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14919.19 Da        Isoelectric Point: 7.8605

>T246926 WP_000911333.1 NZ_CP098193:69640-70038 [Escherichia coli]
MLKFMLDTNICIFTMKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT246926 WP_000450520.1 NZ_CP098193:69413-69640 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References