Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4493368..4493865 Replicon chromosome
Accession NZ_CP098192
Organism Escherichia coli strain Z0117EC0116

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NBY24_RS21755 Protein ID WP_001173343.1
Coordinates 4493368..4493541 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID J7RC38
Locus tag NBY24_RS21760 Protein ID WP_001425728.1
Coordinates 4493569..4493865 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY24_RS21745 (4490038) 4490038..4491495 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
NBY24_RS21750 (4491732) 4491732..4493249 + 1518 WP_001295074.1 lysine--tRNA ligase -
NBY24_RS21755 (4493368) 4493368..4493541 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NBY24_RS21760 (4493569) 4493569..4493865 - 297 WP_001425728.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NBY24_RS21765 (4494092) 4494092..4494364 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
NBY24_RS21770 (4494376) 4494376..4494606 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
NBY24_RS21775 (4494787) 4494787..4496418 + 1632 WP_001216487.1 sensor histidine kinase -
NBY24_RS21780 (4496415) 4496415..4497134 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T246923 WP_001173343.1 NZ_CP098192:c4493541-4493368 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11466.99 Da        Isoelectric Point: 4.2544

>AT246923 WP_001425728.1 NZ_CP098192:c4493865-4493569 [Escherichia coli]
MEGKNKFNTYVVSFNYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB J7RC38

References