Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4388791..4389386 Replicon chromosome
Accession NZ_CP098192
Organism Escherichia coli strain Z0117EC0116

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag NBY24_RS21230 Protein ID WP_000239579.1
Coordinates 4388791..4389141 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag NBY24_RS21235 Protein ID WP_001223208.1
Coordinates 4389135..4389386 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY24_RS21210 (4384067) 4384067..4385089 - 1023 WP_001339490.1 ABC transporter permease -
NBY24_RS21215 (4385103) 4385103..4386605 - 1503 WP_000205793.1 sugar ABC transporter ATP-binding protein -
NBY24_RS21220 (4386915) 4386915..4387871 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NBY24_RS21225 (4388181) 4388181..4388711 + 531 WP_000055072.1 inorganic diphosphatase -
NBY24_RS21230 (4388791) 4388791..4389141 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
NBY24_RS21235 (4389135) 4389135..4389386 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NBY24_RS21240 (4389599) 4389599..4389940 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NBY24_RS21245 (4389943) 4389943..4393722 - 3780 WP_000060921.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T246922 WP_000239579.1 NZ_CP098192:c4389141-4388791 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT246922 WP_001223208.1 NZ_CP098192:c4389386-4389135 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References