Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3650381..3650999 Replicon chromosome
Accession NZ_CP098192
Organism Escherichia coli strain Z0117EC0116

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NBY24_RS17675 Protein ID WP_001291435.1
Coordinates 3650781..3650999 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NBY24_RS17670 Protein ID WP_000344800.1
Coordinates 3650381..3650755 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY24_RS17660 (3645470) 3645470..3646663 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NBY24_RS17665 (3646686) 3646686..3649835 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NBY24_RS17670 (3650381) 3650381..3650755 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NBY24_RS17675 (3650781) 3650781..3650999 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NBY24_RS17680 (3651171) 3651171..3651722 + 552 WP_000102568.1 maltose O-acetyltransferase -
NBY24_RS17685 (3651838) 3651838..3652308 + 471 WP_000136192.1 YlaC family protein -
NBY24_RS17690 (3652472) 3652472..3654022 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NBY24_RS17695 (3654064) 3654064..3654417 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NBY24_RS17705 (3654796) 3654796..3655107 + 312 WP_000409911.1 MGMT family protein -
NBY24_RS17710 (3655138) 3655138..3655710 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T246921 WP_001291435.1 NZ_CP098192:3650781-3650999 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT246921 WP_000344800.1 NZ_CP098192:3650381-3650755 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References