Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1501729..1502354 Replicon chromosome
Accession NZ_CP098192
Organism Escherichia coli strain Z0117EC0116

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NBY24_RS07375 Protein ID WP_000911330.1
Coordinates 1501956..1502354 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NBY24_RS07370 Protein ID WP_000450524.1
Coordinates 1501729..1501956 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY24_RS07345 (1497533) 1497533..1498003 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
NBY24_RS07350 (1498003) 1498003..1498575 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NBY24_RS07355 (1498721) 1498721..1499599 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
NBY24_RS07360 (1499616) 1499616..1500650 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
NBY24_RS07365 (1500863) 1500863..1501576 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NBY24_RS07370 (1501729) 1501729..1501956 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NBY24_RS07375 (1501956) 1501956..1502354 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
NBY24_RS07380 (1502501) 1502501..1503364 + 864 WP_001267507.1 neutral zinc metallopeptidase -
NBY24_RS07385 (1503379) 1503379..1505394 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
NBY24_RS07390 (1505468) 1505468..1506166 + 699 WP_000679823.1 esterase -
NBY24_RS07395 (1506276) 1506276..1506476 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T246914 WP_000911330.1 NZ_CP098192:1501956-1502354 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT246914 WP_000450524.1 NZ_CP098192:1501729-1501956 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References