Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1058305..1058959 Replicon chromosome
Accession NZ_CP098192
Organism Escherichia coli strain Z0117EC0116

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag NBY24_RS05240 Protein ID WP_000244777.1
Coordinates 1058552..1058959 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NBY24_RS05235 Protein ID WP_000354046.1
Coordinates 1058305..1058571 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY24_RS05210 (1053593) 1053593..1054336 + 744 WP_000951948.1 SDR family oxidoreductase -
NBY24_RS05215 (1054393) 1054393..1055826 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
NBY24_RS05220 (1055871) 1055871..1056182 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
NBY24_RS05225 (1056346) 1056346..1057005 + 660 WP_000250274.1 hemolysin III family protein -
NBY24_RS05230 (1057082) 1057082..1058062 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
NBY24_RS05235 (1058305) 1058305..1058571 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NBY24_RS05240 (1058552) 1058552..1058959 + 408 WP_000244777.1 protein YgfX Toxin
NBY24_RS05245 (1058999) 1058999..1059520 - 522 WP_001055874.1 flavodoxin FldB -
NBY24_RS05250 (1059632) 1059632..1060528 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NBY24_RS05255 (1060553) 1060553..1061263 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NBY24_RS05260 (1061269) 1061269..1063002 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T246911 WP_000244777.1 NZ_CP098192:1058552-1058959 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT246911 WP_000354046.1 NZ_CP098192:1058305-1058571 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References