Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 15538..16085 Replicon plasmid pZ0117EC0117-4
Accession NZ_CP098191
Organism Escherichia coli strain Z0117EC0117

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag NBY25_RS25310 Protein ID WP_001384452.1
Coordinates 15538..15816 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0S0ZPX5
Locus tag NBY25_RS25315 Protein ID WP_032291093.1
Coordinates 15816..16085 (-) Length 90 a.a.

Genomic Context

NBY25_RS25295NBY25_RS25300NBY25_RS25330NBY25_RS25335NBY25_RS25340NBY25_RS25290NBY25_RS25305NBY25_RS25310NBY25_RS25315NBY25_RS25320NBY25_RS25325
Location: 13167..13769 (603 bp)
Type: Others
Protein ID: WP_032291854.1
Location: 13825..14334 (510 bp)
Type: Others
Protein ID: WP_032291091.1
Location: 18985..19143 (159 bp)
Type: Others
Protein ID: Protein_20
Location: 19181..19468 (288 bp)
Type: Others
Protein ID: WP_000074855.1
Location: 19910..20443 (534 bp)
Type: Others
Protein ID: WP_001372168.1
Location: 11717..12814 (1098 bp)
Type: Others
Protein ID: Protein_12
Location: 14650..15498 (849 bp)
Type: Others
Protein ID: WP_032291092.1
Location: 15538..15816 (279 bp)
Type: Toxin
Protein ID: WP_001384452.1
Location: 15816..16085 (270 bp)
Type: Antitoxin
Protein ID: WP_032291093.1
Location: 16140..16298 (159 bp)
Type: Others
Protein ID: WP_038349023.1
Location: 16996..18027 (1032 bp)
Type: Others
Protein ID: WP_052991836.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NBY25_RS25290 (11717)11717..12814-1098Protein_12protein YagA-
NBY25_RS25295 (13167)13167..13769+603WP_032291854.1ProQ/FINO family protein-
NBY25_RS25300 (13825)13825..14334+510WP_032291091.1hypothetical protein-
NBY25_RS25305 (14650)14650..15498-849WP_032291092.13'-5' exonuclease-
NBY25_RS25310 (15538)15538..15816-279WP_001384452.1type II toxin-antitoxin system toxin YacBToxin
NBY25_RS25315 (15816)15816..16085-270WP_032291093.1type II toxin-antitoxin system antitoxin YacAAntitoxin
NBY25_RS25320 (16140)16140..16298-159WP_038349023.1hypothetical protein-
NBY25_RS25325 (16996)16996..18027-1032WP_052991836.1plasmid replication initiator RepA-
NBY25_RS25330 (18985)18985..19143+159Protein_20ash family protein-
NBY25_RS25335 (19181)19181..19468+288WP_000074855.1conjugal transfer protein TraA-
NBY25_RS25340 (19910)19910..20443+534WP_001372168.1transcription termination/antitermination NusG family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideConjugative plasmidblaCTX-M-14-1..9118891188


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T246900 WP_001384452.1 NZ_CP098191:c15816-15538 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10069.43 Da        Isoelectric Point: 8.0565

>AT246900 WP_032291093.1 NZ_CP098191:c16085-15816 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLGCGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A829CL36

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0S0ZPX5

References