Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 15538..16085 Replicon plasmid pZ0117EC0117-4
Accession NZ_CP098191
Organism Escherichia coli strain Z0117EC0117

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag NBY25_RS25310 Protein ID WP_001384452.1
Coordinates 15538..15816 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0S0ZPX5
Locus tag NBY25_RS25315 Protein ID WP_032291093.1
Coordinates 15816..16085 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY25_RS25290 (11717) 11717..12814 - 1098 Protein_12 protein YagA -
NBY25_RS25295 (13167) 13167..13769 + 603 WP_032291854.1 ProQ/FINO family protein -
NBY25_RS25300 (13825) 13825..14334 + 510 WP_032291091.1 hypothetical protein -
NBY25_RS25305 (14650) 14650..15498 - 849 WP_032291092.1 3'-5' exonuclease -
NBY25_RS25310 (15538) 15538..15816 - 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
NBY25_RS25315 (15816) 15816..16085 - 270 WP_032291093.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
NBY25_RS25320 (16140) 16140..16298 - 159 WP_038349023.1 hypothetical protein -
NBY25_RS25325 (16996) 16996..18027 - 1032 WP_052991836.1 plasmid replication initiator RepA -
NBY25_RS25330 (18985) 18985..19143 + 159 Protein_20 ash family protein -
NBY25_RS25335 (19181) 19181..19468 + 288 WP_000074855.1 conjugal transfer protein TraA -
NBY25_RS25340 (19910) 19910..20443 + 534 WP_001372168.1 transcription termination/antitermination NusG family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-14 - 1..91188 91188


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T246900 WP_001384452.1 NZ_CP098191:c15816-15538 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10069.43 Da        Isoelectric Point: 8.0565

>AT246900 WP_032291093.1 NZ_CP098191:c16085-15816 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLGCGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A0S0ZPX5

References