Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1382029..1382647 Replicon chromosome
Accession NZ_CP098187
Organism Escherichia coli strain Z0117EC0117

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NBY25_RS06590 Protein ID WP_001291435.1
Coordinates 1382029..1382247 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NBY25_RS06595 Protein ID WP_000344800.1
Coordinates 1382273..1382647 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY25_RS06555 (1377317) 1377317..1377889 + 573 WP_000779844.1 YbaY family lipoprotein -
NBY25_RS06560 (1377920) 1377920..1378231 - 312 WP_000409908.1 MGMT family protein -
NBY25_RS06570 (1378610) 1378610..1378963 + 354 WP_000878142.1 DUF1428 family protein -
NBY25_RS06575 (1379005) 1379005..1380555 - 1551 WP_001468081.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NBY25_RS06580 (1380719) 1380719..1381189 - 471 WP_000136192.1 YlaC family protein -
NBY25_RS06585 (1381305) 1381305..1381856 - 552 WP_000102539.1 maltose O-acetyltransferase -
NBY25_RS06590 (1382029) 1382029..1382247 - 219 WP_001291435.1 HHA domain-containing protein Toxin
NBY25_RS06595 (1382273) 1382273..1382647 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NBY25_RS06600 (1383192) 1383192..1386341 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NBY25_RS06605 (1386364) 1386364..1387557 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T246887 WP_001291435.1 NZ_CP098187:c1382247-1382029 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT246887 WP_000344800.1 NZ_CP098187:c1382647-1382273 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References