Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 512835..513332 Replicon chromosome
Accession NZ_CP098187
Organism Escherichia coli strain Z0117EC0117

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NBY25_RS02455 Protein ID WP_001173343.1
Coordinates 513159..513332 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag NBY25_RS02450 Protein ID WP_001312331.1
Coordinates 512835..513131 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY25_RS02430 (509564) 509564..510283 - 720 WP_000611288.1 two-component system response regulator DcuR -
NBY25_RS02435 (510280) 510280..511911 - 1632 WP_001216466.1 sensor histidine kinase -
NBY25_RS02440 (512092) 512092..512322 + 231 WP_000373291.1 4Fe-4S mono-cluster protein YjdI -
NBY25_RS02445 (512334) 512334..512606 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
NBY25_RS02450 (512835) 512835..513131 + 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NBY25_RS02455 (513159) 513159..513332 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NBY25_RS02460 (513451) 513451..514968 - 1518 WP_000003805.1 lysine--tRNA ligase -
NBY25_RS02465 (515205) 515205..516662 - 1458 WP_250781975.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T246884 WP_001173343.1 NZ_CP098187:513159-513332 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT246884 WP_001312331.1 NZ_CP098187:512835-513131 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References