Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4405047..4405678 Replicon chromosome
Accession NZ_CP098183
Organism Escherichia coli strain Z0117EC0133

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag NBY27_RS21545 Protein ID WP_001259385.1
Coordinates 4405403..4405678 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag NBY27_RS21540 Protein ID WP_000593555.1
Coordinates 4405047..4405406 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY27_RS21510 (4400159) 4400159..4400632 + 474 WP_001161650.1 PTS sugar transporter subunit IIA -
NBY27_RS21515 (4400629) 4400629..4400910 + 282 WP_000084025.1 PTS sugar transporter subunit IIB -
NBY27_RS21520 (4400987) 4400987..4402345 + 1359 WP_021565455.1 PTS galactitol transporter subunit IIC -
NBY27_RS21525 (4402338) 4402338..4403846 + 1509 WP_021565454.1 FGGY-family carbohydrate kinase -
NBY27_RS21530 (4403836) 4403836..4404105 + 270 WP_000933061.1 HPr family phosphocarrier protein -
NBY27_RS21535 (4404137) 4404137..4404997 + 861 WP_001131788.1 class II aldolase -
NBY27_RS21540 (4405047) 4405047..4405406 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NBY27_RS21545 (4405403) 4405403..4405678 - 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
NBY27_RS21550 (4405737) 4405737..4406861 - 1125 WP_021565453.1 ABC transporter permease -
NBY27_RS21555 (4406861) 4406861..4409596 - 2736 WP_064484666.1 ribosome-associated ATPase/putative transporter RbbA -
NBY27_RS21560 (4409593) 4409593..4410660 - 1068 WP_021565451.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4399388..4414499 15111


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T246876 WP_001259385.1 NZ_CP098183:c4405678-4405403 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT246876 WP_000593555.1 NZ_CP098183:c4405406-4405047 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References