Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3363262..3363887 Replicon chromosome
Accession NZ_CP098183
Organism Escherichia coli strain Z0117EC0133

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NBY27_RS16385 Protein ID WP_000911330.1
Coordinates 3363262..3363660 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NBY27_RS16390 Protein ID WP_000450524.1
Coordinates 3363660..3363887 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY27_RS16365 (3359169) 3359169..3359369 + 201 WP_000383836.1 YpfN family protein -
NBY27_RS16370 (3359450) 3359450..3360148 - 699 WP_000679812.1 esterase -
NBY27_RS16375 (3360222) 3360222..3362237 - 2016 WP_021565358.1 tRNA cytosine(34) acetyltransferase TmcA -
NBY27_RS16380 (3362252) 3362252..3363115 - 864 WP_001267508.1 neutral zinc metallopeptidase -
NBY27_RS16385 (3363262) 3363262..3363660 - 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
NBY27_RS16390 (3363660) 3363660..3363887 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NBY27_RS16395 (3364041) 3364041..3364754 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NBY27_RS16400 (3364967) 3364967..3366001 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
NBY27_RS16405 (3366018) 3366018..3366896 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
NBY27_RS16410 (3367042) 3367042..3367614 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NBY27_RS16415 (3367614) 3367614..3368084 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T246872 WP_000911330.1 NZ_CP098183:c3363660-3363262 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT246872 WP_000450524.1 NZ_CP098183:c3363887-3363660 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References