Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2020486..2020957 Replicon chromosome
Accession NZ_CP098183
Organism Escherichia coli strain Z0117EC0133

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag NBY27_RS09670 Protein ID WP_001303511.1
Coordinates 2020486..2020764 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag NBY27_RS09675 Protein ID WP_001302048.1
Coordinates 2020766..2020957 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY27_RS09640 (2015590) 2015590..2018061 - 2472 WP_096982411.1 exonuclease -
NBY27_RS09645 (2018155) 2018155..2018346 - 192 WP_096982410.1 DUF1482 family protein -
NBY27_RS09650 (2018343) 2018343..2018531 - 189 WP_000854558.1 cell division inhibition protein DicB -
NBY27_RS09655 (2019070) 2019070..2019525 + 456 WP_000559912.1 hypothetical protein -
NBY27_RS09660 (2019661) 2019661..2019879 - 219 WP_096982557.1 protein YdfC -
NBY27_RS24990 (2019909) 2019909..2020037 - 129 WP_284709454.1 hypothetical protein -
NBY27_RS09665 (2020039) 2020039..2020194 - 156 WP_000379577.1 DUF1391 family protein -
NBY27_RS09670 (2020486) 2020486..2020764 - 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY27_RS09675 (2020766) 2020766..2020957 - 192 WP_001302048.1 hypothetical protein Antitoxin
NBY27_RS09680 (2020978) 2020978..2021349 - 372 WP_001169685.1 hypothetical protein -
NBY27_RS09685 (2021447) 2021447..2021749 + 303 WP_000172735.1 transcriptional regulator -
NBY27_RS09690 (2021746) 2021746..2022171 + 426 WP_212541399.1 toxin YdaT family protein -
NBY27_RS09695 (2022196) 2022196..2023143 + 948 WP_094336148.1 helix-turn-helix domain-containing protein -
NBY27_RS09700 (2023186) 2023186..2023587 + 402 WP_064578958.1 DUF977 family protein -
NBY27_RS09705 (2023584) 2023584..2023883 + 300 WP_001266136.1 DUF4406 domain-containing protein -
NBY27_RS09710 (2023876) 2023876..2024340 + 465 WP_250790903.1 hypothetical protein -
NBY27_RS09715 (2024318) 2024318..2024674 + 357 WP_001541651.1 hypothetical protein -
NBY27_RS09720 (2024725) 2024725..2024937 + 213 WP_032083143.1 hypothetical protein -
NBY27_RS09725 (2024970) 2024970..2025188 + 219 WP_135565446.1 DUF4014 family protein -
NBY27_RS09730 (2025190) 2025190..2025480 + 291 Protein_1882 DUF551 domain-containing protein -
NBY27_RS09735 (2025778) 2025778..2025933 + 156 WP_089616915.1 type I toxin-antitoxin system toxin HokD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2010034..2062045 52011


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T246861 WP_001303511.1 NZ_CP098183:c2020764-2020486 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT246861 WP_001302048.1 NZ_CP098183:c2020957-2020766 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References